Senior Research Scientist – Neuroscience

Job Overview

Arvinas is a biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins.

Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer PROteolysis TArgeting Chimeras, or PROTACs, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

Job Description

Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in May 2026 with the first-ever U. S. Food and Drug Administration (FDA) approval of a PROTAC protein degrader therapy.

The approval marked a significant advancement for the field and demonstrated the therapeutic potential of targeted protein degradation as a novel treatment modality. This PROTAC has been out-licensed for commercialization and further development.

#TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back.

They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform.

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say .

Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www. arvinas. com and connect on LinkedIn and X .

Key Responsibilities

• This differentiated approach has enabled Arvinas to build a broad pipeline of investigational therapies across oncology and neurodegenerative diseases, including ARV-102, targeting LRRK2 for neurodegenerative diseases; ARV-806, targeting KRAS G12D for mutated cancers, including pancreatic, colorectal, and non-small cell lung cancers; ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle for spinal bulbar muscular atrophy; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer.
• Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in May 2026 with the first-ever U.S.
• We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too.
• Position Summary We are seeking an experienced and highly motivated Research Scientist/Senior Research Scientist to lead and execute cellular and tissue-based target engagement studies of small molecule ligands and targeted protein degraders (e.g., PROTACs).
• Principal Responsibilities Key responsibilities of this role include, but are not limited to: Design, develop, optimize, and validate cellular and biochemical assays to measure target engagement and degradation driven by small molecules and targeted protein degraders.
• Adapt assays for medium- to high-throughput screening to support compound profiling, degrader optimization, and screening campaigns.
• Experience adapting assays for robustness, scalability, miniaturization, and multi-well plate formats to support compound profiling or screening workflows.
• The duties of this role are generally conducted in a lab environment.

Required Skills and Qualifications

• Position Summary We are seeking an experienced and highly motivated Research Scientist/Senior Research Scientist to lead and execute cellular and tissue-based target engagement studies of small molecule ligands and targeted protein degraders (e.g., PROTACs).
• Qualifications Deep hands-on experience (3+ years) developing and executing cellular or tissue-based assays for small-molecule target engagement, degradation, or specificity assessment.
• Experience using probe-based or proximity-based strategies, such as biotinylated probes, photoaffinity labeling, NanoBRET, TR-FRET, AlphaLISA, luciferase-based assays, or related approaches.
• Experience adapting assays for robustness, scalability, miniaturization, and multi-well plate formats to support compound profiling or screening workflows.
• Strong data analysis skills using tools such as Prism, Gene Data, Python, or R.
• Track record of scientific contributions (publications, patents, or program impact) and cross-functional collaboration skills.
• Experience working with rodent and human-derived tissues (e.g., post-mortem brain) a plus.
• You must have the ability to work without a need for current or future VISA sponsorship.

Benefits and Perks

• This differentiated approach has enabled Arvinas to build a broad pipeline of investigational therapies across oncology and neurodegenerative diseases, including ARV-102, targeting LRRK2 for neurodegenerative diseases; ARV-806, targeting KRAS G12D for mutated cancers, including pancreatic, colorectal, and non-small cell lung cancers; ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle for spinal bulbar muscular atrophy; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer.
• #LI-Remote Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families.
• Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more.

Work Location and Schedule

This role is listed as Remote USA with location information shown as Remote USA. The employment type is Full Time.

About the Company

Arvinas is the organization connected with this listing. USA Jobs Today displays this opportunity for job discovery only, so applicants should verify company details, application instructions, and eligibility on the official employer website.